Health data are essential for research and innovation in health, yet these data are often under-used because they remain too scattered. The HDH was hence conceived as the unique gateway to health data in France. Implemented in November 2019, it interacts with a variety of actors within the health ecosystem. The Health Data Hub has set up a highly efficient technological platform enabling public interest project leaders to mobilise very large data sources, to cross-reference them, and to use enough computing power to run complex search algorithms. In a word, the HDH supports ambitious project leaders who contribute to finding tomorrow’s solutions to improve all citizens’ health.